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Centeno EGZ, Moreni G, Vriend C, Douw L, Santos FAN. A hands-on tutorial on network and topological neuroscience. bioRxiv.

Numan T, Kulik SD, Moraal B, Reijneveld JC, Stam CJ, de Witt Hamer PC, Derks J, Bruynzeel AME, van Linde ME, Wesseling P, Kouwenhoven MCM, Klein M, Wurdinger T, Barkhof F, Geurts JJG, Hillebrand A, Douw L. Non-invasively measured brain activity and radiological progression in diffuse glioma. medRxiv

Douw L, Nissen IA, Fitzsimmons SMDD, Santos FAN, Hillebrand A, van Straaten ECW, Stam CJ, de Witt Hamer PC, Baayen JC, Klein M, Reijneveld JC, Heyer DB, Verhoog MB, Wilbers R, Hunt S, Mansvelder HD, Geurts JJG, de Kock CPJ, Goriounova NA. Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy. bioRxiv.

Douw L, Miller JJ, Steenwijk MD, Stufflebeam SM, Gerstner ER. Altered hub connectivity and its clinical relevance in glioma. Biorxiv.


Schoonheim MM, Douw L, Broeders TAA, Eijlers AJC, Meijer KA, Geurts JJG (2021). The cerebellum and its network: disrupted static and dynamic functional connectivity patterns and cognitive impairment in multiple sclerosis. Multiple Sclerosis Journal, in press.

Tijhuis FB, Broeders TAA, Santos FAN, Schoonheim MM, Killestein J, Leurs CE, van Geest Q, Steenwijk MD, Geurts JJG, Hulst HE, Douw L (2021). Dynamic functional connectivity as a neural correlate of fatigue in multiple sclerosis. NeuroImage:Clinical 29.


Nauta IM, Kulik SD, Breedt LC, Eijlers AJC, Strijbis EMM, Bertens D, Tewarie P, Hillebrand A, Stam CJ, Uitdehaag BMJ, Geurts JJG, Douw L, de Jong BA, Schoonheim MM (2020). Functional brain network organization measured with magnetoencephalography predicts cognitive decline in multiple sclerosis. Multiple Sclerosis Journal doi: 10.1177/1352458520977160.

Brooks D, Hulst HE, de Bruin L, Glas G, Geurts JJG, Douw L (2020). The multilayer network approach in the study of personality neuroscience. Brain Sciences 10(12); 915.

Jonkman LE, Steenwijk MD, Boesen N, Rozemuller AJM, Barkhof F, Geurts JJG, Douw L, van de Berg WDJ (2020). Relationship between beta-amyloid and structural network topology in decedents without dementia. Neurology 95:e532-e544.

Fitzsimmons SMDD, Douw L, van den Heuvel OA, van der Werf YD, Vriend C (2020). Resting-state and task-based centrality of dorsolateral prefrontal cortex predict resilience to 1 Hz repetitive transcranial magnetic stimulation. Human Brain Mapping 41:3161-3171.

Nieboer D, Sorrentino P, Hillebrand A, Heymans M, Twisk J, Stam CJ, Douw L (2020). Brain network integration in patients with migraine: a magnetoencephalography study. Brain Connectivity 10:224-235.

Tewarie P, Prasse B, Meier JM, Santos FAN, Douw L, Schoonheim MM, Stam CJ, Van Mieghem P, Hillebrand A (2020). Mapping functional brain networks from the structural connectome: relating the series expansion and eigenmode approaches. NeuroImage 216:116805.

Douw L, Quaak M, Fitzsimmons SMDD, de Wit SJ, van der werf YD, van den Heuvel OA, Vriend C (2020). Static and dynamic network properties of the repetitive transcranial magnetic stimulation target predict changes in emotion regulation in obsessive-compulsive disorder. Brain Stimulation 13(2):318-326.

DeSalvo MN, Tanaka N, Douw L, Cole AJ, Stufflebeam SM (2020). Contralateral preoperative resting-state functional MRI network integration is associated with surgical outcome in temporal lobe epilepsy. Radiology 294:622–627.

Belgers V, Numan T, Kulik SD, Hillebrand A, de Witt Hamer PC, Geurts JJG, Reijneveld JC, Wesseling P, Klein M, Derks J, Douw L (2020). Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma. Journal of Neuro-Oncology 147:49-58.

Meijer KA, Steenwijk MD, Douw L, Schoonheim MM, Geurts JJG (2020). Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis. Brain 143:150-160.

van Dongen L, Westerik B, van der Hiele K, Visser LH, Schoonheim MM, Douw L, Twisk JWR, de Jong BA, Geurts JJG, Hulst HE (2020). Introducing Multiple Screener: an unsupervised digital screening tool for cognitive deficits in MS. Multiple Sclerosis and Related Disorders 38:101479.

Lurie DJ, Kessler D, Bassett DS, Betzel RF, Breakspear M, Keilholz S, Kucyi A, Liegois R, Lindquist MA, McIntosh AR, Poldrack RA, Shine JM, Thompson WH, Bielczyk NZ, Douw L, Kraft D, Miller RL, Muthuraman M, Pasquini L, Razi A, Vidaurre D, Xie H, Calhoun VD (2019). Questions and controversies in the study of time-varying functional connectivity in resting fMRI. Network Neuroscience 4:30-69.


Santos FAN, Raposo EP, Coutinho-Filho MD, Copelli M, Stam CJ, Douw L (2019). Topological phase transitions in functional brain networks. Physical Review E 100; 032414.

Douw L, van Dellen E, Gouw AA, Griffa A, de Haan W, van den Heuvel M, Hillebrand A, Van Mieghem P, Nissen IA, Otte WM, Reijmer YD, Schoonheim MM, Senden M, van Straaten ECW, Tijms BM, Tewarie P, Stam CJ (2019). The road ahead in clinical network neuroscience. Network Neuroscience 3:969-993.

Habets EJJ, Hendriks EJ, Taphoorn MJB, Douw L, Zwinderman AH, Vandertop WP, Barkhof F, De Witt Hamer PC, Klein M (2019). Association between tumor location and neurocognitive functioning using tumor localization maps. Journal of Neuro-Oncology 144:573-582.

Engels G, Douw L, Kerst Y, Weinstein H, Scherder E, Vlaar A (2019). Non-motor symptoms in Parkinson’s disease: an explorative network study. Parkinsonism & related disorders 66:237-240.

Eijlers EJC, Wink AM, Meijer KA, Douw L, Geurts JJG, Schoonheim MM (2019). Reduced network dynamics on functional MRI signals cognitive impairment in multiple sclerosis. Radiology 292:449-457.

Eijlers EJC, Wink AM, Meijer KA, Douw L, Geurts JJG, Schoonheim MM (2019). Functional network dynamics on functional MRI: a primer on an emerging frontier in neuroscience. Radiology 292:460-463.

Derks J, Kulik S, Wesseling P, Numan T, Hillebrand A, van Dellen E, De Witt Hamer PC, Geurts JJG, Reijneveld JC, Stam CJ, Klein M, Douw L (2019). Understanding cognitive functioning in glioma patients: the relevance of IDH-mutation status and functional connectivity. Brain and Behavior 9:e01204.

Kiljan S, Meijer KA, Steenwijk MD, Pouwels PJW, Schoonheim MM, Schenk GJ, Geurts JJG, Douw L (2019). Structural network topology relates to tissue properties in multiple sclerosis. Journal of Neurology 266(1):212-222.


Engels G, Vlaar A, McCoy B, Scherder E, Douw L (2018). Dynamic functional connectivity and symptoms of Parkinson’s Disease: a resting-state fMRI study. Frontiers in Aging Neuroscience

Van Montfort SJT, Numan T, van Dellen E, Kyeong S, Douw L, Kim JJ (2018). Delirium is not associated with altered hub flexibility of the posterior cingulate cortex. Clinical Neurophysiology 129(12):2541-2543.

Van Nieuwenhuizen D, Douw L, Klein M, Peerdeman SM, Heimans JJ, Reijneveld JC, Stam CJ, Hillebrand A (2018). Cognitive functioning and functional brain networks in postoperative WHO grade I meningioma patients. Journal of Neuro-Oncology 140:605-613.

Ventura N, Douw L, Correa DG, Netto TM, Cabral RF, Lopes FCR, Gasparetto EL (2018). Increased posterior cortex efficiency may predict cognitive impairment in asymptomatic HIV patients. Neuroradiology Journal 31(4):371-378.

Engels G, McCoy B, Vlaar A, Theeuwes J, Weinstein H, Scherder E, Douw L (2018). Clinical pain and functional network topology in Parkinson’s disease: a resting-state fMRI study. Journal of Neural Transmission 125(1):1449:1459.

Derks J, Wesseling P, Carbo EWS, Hillebrand A, van Dellen A, de Witt Hamer PC, Klein M, Schenk GJ, Geurts JJG, Reijneveld JC, Douw L (2018). Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma. Journal of Neuro-Oncology 140:403-412.

Vriend C, van den Heuvel OA, Berendse HW, van der Werf YD, Douw L (2018). Global and subnetwork changes of the structural connectome in de novo Parkinson’s disease. Neuroscience 386:295-308.

Van Geest Q, Douw L, Van ‘t Klooster S, Leurs CE, Genova HM, Wylie GR, Steenwijk MD, Killestein J, Geurts JJG, Hulst HE (2018). Information processing speed in multiple sclerosis: relevance of default mode dynamics. NeuroImage: Clinical 19:507-515.

Van Geest Q, Hulst HE, Meijer KA, Hoyng L, Geurts JJG, Douw L (2018). The importance of hippocampal dynamic connectivity in explaining memory function in multiple sclerosis. Brain and Behavior 8(5):e00954.

Hendriks EJ, Habets EJJ, Taphoorn MJB, Douw L, Zwinderman AH, Vandertop WP, Barkhof F, Klein M, De Witt Hamer PC (2018). Linking late cognitive outcome with glioma surgery location using resection cavity maps. Human Brain Mapping 39(5):2064-2074.

Van Dellen E, Sommer IE, Bohlken MM, Tewarie P, Draaisma L, Zalesky A, Di Biase M, Brown JA, Douw L, Otte WM, Mandl RCW, Stam CJ (2018). Minimum spanning tree analysis of the human connectome. Human Brain Mapping 39(6):2455-2471.

Douw L, Nieboer D, Stam CJ, Tewarie P, Hillebrand A (2017). Consistency of magnetoencephalographic functional connectivity and network reconstruction using a template versus native MRI for co-registration. Human Brain Mapping 39(1):104-119.


Tang W, Liu H, Douw L, Kramer MA, Eden UT, Hamalainen MS, Stufflebeam SM (2017). Dynamic connectivity modulates local activity in the core regions of the default-mode network. PNAS 114(36):9713-9718.

Sorrentino P, Nieboer D, Twisk J, Stam CJ, Douw L, Hillebrand A (2017). The hierarchy of brain networks is related to insulin growth factor-1 in a large, middle-aged, healthy cohort: an exploratory magnetoencephalography study. Brain Connectivity 7(5):321-330.

Meijer KA, Eijlers AJC, Douw L, Uitdehaag BMJ, Barkhof F, Geurts JJG, Schoonheim MM (2017). Increased connectivity of hub networks and cognitive impairment in multiple sclerosis. Neurology 88(22):2107-2114.

Carbo EWS, Hillebrand A, van Dellen E, Tewarie P, de Witt Hamer PC, Baayen JC, Klein M, Geurts JJG, Reijneveld JC, Stam CJ, Douw L (2017). Dynamic hub load predicts cognitive decline after resective neurosurgery. Scientific Reports 7:42117.

Derks J, Dirkson AR, de Witt Hamer PC, van Geest Q, Hulst HE, Barkhof F, Pouwels PJW, Geurts JJG, Reijneveld JC, Douw L. Connectomic profile and clinical phenotype in newly diagnosed glioma patients. NeuroImage:Clinical 14:87-96.

Sjoerds Z, Stufflebeam SM, Veltman DJ, Van den Brink W, Penninx BW, Douw L (2017). Loss of brain graph network efficiency in alcohol dependence. Addiction Biology 22(2):523-534.


Nieboer D, Douw L, van Dijk BW, Heymans MW, Stam CJ, Twisk JWR (2016). Relation between carotid stiffness, cognitive performance and brain connectivity in a healthy middle-aged population: an observational neurophysiological cohort study with magnetoencephalography. BMJ open 6: e013441.

Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, Jain RK, Batchelor TT, Gerstner ER (2016). Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. Journal of Neuro-Oncology 131(3):603-610.

Douw L, Wakeman DG, Tanaka N, Liu H, Stufflebeam SM (2016). State-dependent variability of dynamic functional connectivity between frontoparietal and default networks relates to cognitive flexibility. Neuroscience 339:12-21.

DeSalvo MN, Tanaka N, Douw L, Leveroni CL, Buchbinder BR, Greve DN, Stufflebeam SM (2016). Resting-state functional MR imaging for determining language laterality in intractable epilepsy. Radiology 281 (1):264-269.

Hillebrand A, Tewarie P, van Dellen E, Yu M, Carbo EWS, Douw L, Gouw AA, van Straaten ECW, Stam CJ (2016). Direction of information flow in large-scale resting-state networks is frequency-dependent. PNAS 113(14):3867-3872.

Meier J, Tewarie P, Hillebrand A, Douw L, van Dijk B, Stufflebeam SM, Van Mieghem PF (2016). A mapping between structural and functional brain networks. Brain Connectivity 6(4):298-311.


Reddy L, Poncet M, Self MW, Peters JC, Douw L, van Dellen E, Claus S, Reijneveld JC, Baayen JC, Roelfsema PR (2015). Learning of anticipatory responses in single neurons of the human medial temporal lobe. Nature Communications 6; 8556.

Douw L, Leveroni C, Tanaka N, Emerton C, Cole AJ, Liu H, Reinsberger C, Stufflebeam SM (2015). Loss of resting-state posterior cingulate flexibility is associated with memory disturbance in left temporal lobe epilepsy. PLoS ONE 10(6): e0131209

Douw L, DeSalvo MN, Tanaka N, Cole AJ, Liu H, Reinsberger C, Stufflebeam SM (2015). Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Annals of Clinical and Translational Neurology 2(4): 338–352.

Boele F, Douw L, Reijneveld JC, Robben R, Taphoorn MJ, Aaronson NK, Heimans JJ, Klein M (2015). Health-related quality of life in stable, long-term low-grade glioma survivors. Journal of Clinical Oncology 33(9): 1023-1029.


LaPlante RA, Stufflebeam SM, Douw L, Tang W (2014).  The connectome visualization utility: software for visualization of multi-modal human brain networks. PLoS ONE 9(12): e113838.

DeSalvo MN, Douw L, Takaya S, Liu H, Stufflebeam SM (2014). Task-dependent reorganization of functional connectivity networks during visual semantic decision making. Brain and Behavior: doi: 10.1002/brb3.286

Derks J, Reijneveld JC, Douw L (2014). Neural network alterations underlie cognitive deficits in brain tumor patients. Current Opinions in Oncology 26(6): 627-633.

Douw L, Nieboer D, van Dijk BW, Stam CJ, Twisk JWR (2014). A healthy brain in a healthy body: brain network correlates of physical and mental fitness. PLoS ONE 9(2): e88202.

DeSalvo MN, Douw L, Tanaka N, Reinsberger C, Stufflebeam SM (2014). Altered structural connectome in mesial temporal lobe epilepsy. Radiology 270(3): 842-848.

Van Dellen E, Douw L, Hillebrand A, De Witt Hamer PC, Baayen JC, Heimans JJ, Reijneveld JC, Stam CJ (2014). Epilepsy surgery outcome and functional network alterations in longitudinal MEG: a minimum spanning tree analysis. NeuroImage 86:354-363.

Froklage FE, Oosterbaan LJ, Sizoo EM, de Groot M, Bosma I, Sanchez E, Douw L, Heimans JJ, Reijneveld JC, Lagerwaard FJ, Buter J, Uitdehaag BMJ, Klein M, Postma TJ (2014). Central neurotoxicity of standard treatment in patients with newly-diagnosed high-grade glioma: a prospective longitudinal study. Journal of Neuro-Oncology 116(2):387-394.


Schoonheim MM, Geurts JJ, Landi D, Douw L, van der Meer ML, Vrenken H, Polman CH, Barkhof F, Stam CJ (2013). Functional connectivity changes in multiple sclerosis patients: A graph analytical study of MEG resting state data. Hum Brain Mapping 34(1):52-61.

Douw L, de Groot M, Sizoo EM, Bosma I, Froklage FE, Heimans JJ, Postma TJ, Klein M, Reijneveld JC (2013). Levetiracetam improves verbal memory in high-grade glioma patients. Neuro Oncol 15(2):216-223.

Van Dellen E, Hillebrand A, Douw L, Heimans JJ, Reijneveld JC, Stam CJ (2013). Local polymorphic delta activity in cortical lesions causes global decreases in functional connectivity. NeuroImage 83:524-532.

Douw L, de Groot M, van Dellen E, Aronica E, Heimans JJ, Klein M, Stam CJ, Reijneveld JC, Hillebrand A (2013). Local MEG networks: the missing link between protein expression and epilepsy in glioma patients? NeuroImage 75:195-203.

Van der Meer EL, Tewarie P, Schoonheim MM, Douw L, Barkhof F, Polman CH, Stam CJ, Hillebrand A (2013). Cognition in MS correlates with resting-state oscillatory brain activity: an explorative MEG source-space study. NeuroImage: Clinical 2:727-734.

Boele F, Douw L, de Groot M, van Thuijl HF, Cleijne W, Heimans JJ, Taphoorn MJB, Reijneveld JC, Klein M (2013). The effect of modafinil on fatigue, cognitive functioning and mood in primary brain tumor patients: a multi-center RCT. Neuro-Oncology 15(10):1420-1428.


Van Dellen E, de Witt Hamer PC, Douw L, Klein M, Heimans JJ, Stam CJ, Reijneveld JC, Hillebrand A (2012). Connectivity in MEG resting-state networks increases after respective surgery for low-grade glioma and correlates with improved cognitive performance. NeuroImage: Clinical 2:1-7.

Schoonheim MM, Popescu V, Rueda Lopes FC, Wiebenga OT, Vrenken H, Douw L, Polman CH, Geurts JJ, Barkhof F (2012). Subcortical atrophy and cognition: sex effects in multiple sclerosis. Neurology 79(17):1754-1761.

Van Dellen E, Douw L, Hillebrand A, Ris-Hilgersom I, Schoonheim MM, Baayen JC, de Witt Hamer PC, Velis DN, Klein M, Heimans JJ, Stam CJ, Reijneveld JC (2012). MEG network differences between low- and high grade glioma related to epilepsy and cognition. PLoS One 7(11);e50122.


Douw L, Schoonheim MM, Landi D, van der Meer ML, Geurts JJ, Reijneveld JC, Klein M, Stam CJ (2011). Cognition is related to resting-state small-world network topology: a magnetoencephalography study. Neuroscience, 175:169-177.


Douw L, Heimans JJ, Taphoorn MJ, Postma TJ, Reijneveld JC, Klein M (2010). [Radiotherapy in patients with low-grade glioma: a correlation with cognitive disorders in the long term]. Ned Tijdschr Geneeskd 154:A1472.

Douw L, de Groot M, van Dellen E, Heimans JJ, Ronner HE, Stam CJ, Reijneveld JC (2010). ‘Functional connectivity’ is a sensitive predictor of epilepsy diagnosis after the first seizure. PLoS One 5:e10839.

Douw L, van Dellen E, de Groot M, Heimans JJ, Klein M, Stam CJ, Reijneveld JC (2010). Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients. BMC Neuroscience 11(1):103.

Wang H, Douw L, Hernández JM, Reijneveld JC, Stam CJ, Van Mieghem P (2010). Effect of tumor resection on the characteristics of functional brain networks. Physical Review E 82:021924.

Douw L, van Dellen E, Baayen JC, Klein M, Velis DN, Alpherts WCJ, Heimans JJ, Reijneveld JC, Stam CJ (2010). The lesioned brain: still a small world? Frontiers in Human Neuroscience 4:174.


Ponten SC, Douw L, Bartolomei F, Reijneveld JC, Stam CJ (2009). Indications for network regularization during absence seizures: weighted and unweighted graph theoretical analyses. Exp Neurol 217:197-204.

Bosma I, Reijneveld JC, Klein M, Douw L, van Dijk BW, Heimans JJ, Stam CJ (2009). Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG. Nonlinear Biomed Phys 3:9.

Bosma I, Reijneveld JC, Douw L, Vos MJ, Postma TJ, Aaronson NK, Muller M, Vandertop WP, Slotman BJ, Taphoorn MJ, Heimans JJ, Klein M (2009). Health-related quality of life of long- term high-grade glioma survivors. Neuro Oncol 11:51-58.

Douw L, Baayen JC, Klein M, Velis D, Alpherts WC, Bot J, Heimans JJ, Reijneveld JC, Stam CJ (2009). Functional connectivity in the brain before and during intra-arterial amobarbital injection (Wada test). Neuroimage 46:584-588.

van Dellen E, Douw L, Baayen JC, Heimans JJ, Ponten SC, Vandertop WP, Velis DN, Stam CJ, Reijneveld JC (2009). Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings. PLoS One 4:e8081.

Douw L, Klein M, Fagel SS, van den Heuvel J, Taphoorn MJ, Aaronson NK, Postma TJ, Vandertop WP, Mooij JJ, Boerman RH, Beute GN, Sluimer JD, Slotman BJ, Reijneveld JC, Heimans JJ (2009). Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol 8:810-818.


Bosma I, Douw L, Bartolomei F, Heimans JJ, van Dijk BW, Postma TJ, Stam CJ, Reijneveld JC, Klein M (2008). Synchronized brain activity and neurocognitive function in patients with low-grade glioma: a magnetoencephalography study. Neuro Oncol 10:734-744.

Bosma I, Stam CJ, Douw L, Bartolomei F, Heimans JJ, van Dijk BW, Postma TJ, Klein M, Reijneveld JC (2008). The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study. J Neurooncol 88:77-85.

Douw L, Baayen H, Bosma I, Klein M, Vandertop P, Heimans J, Stam K, de Munck J, Reijneveld J (2008). Treatment-related changes in functional connectivity in brain tumor patients: A magnetoencephalography study. Exp Neurol 212:285-290.

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