The paper on hub-rich networks in MS by Kim Meijer was put in the spotlight by the editors of Neurology. In this study, cognitive impairment in multiple sclerosis was related to altered communication of hub-rich networks. The default mode and frontoparietal networks showed increased functional connectivity, but only with more peripheral regions (i.e., non-hubs), in cognitively impaired patients. This seemingly negative shift in network balance potentially underlies cognitive dysfunction in multiple sclerosis.
Multiscale Network Neuroscience 